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Clinical evaluation of recombinant human platelet-derived growth factor for the treatment of lower extremity ulcers

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[189]indicated that merely inhibiting GPx4 does not suffice to trigger ferroptosis, implying that prolonged ethanol exposure might disrupt the methionine cycle, eventually leading to significant GSH depletion and the indirect inactivation of GPx4

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Numerous studies have documented the dysregulated expression of IGF ligands, receptors, and IGFBPs, highlighting their associations with AD

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